We want to transform healthcare, change the lives of billions of people for the better and address some of the biggest healthcare challenges facing humankind. Our ambition is to stop the progress of these often degenerative, debilitating, and life-threatening conditions, achieve remission, and one day cure them.

Clean and plentiful water is vital for the development and manufacture of these life-changing medicines. We use freshwater for cleaning and cooling, and we also require relatively small volumes of purified water for chemical syntheses and producing biological medicines. Although water use in our industry is low relative to other sectors, significant volumes of water are required to produce the raw materials we use to make our products and, at a local level, our sites have the potential to deplete water sources and impact water quality. We recognise that it is key to focus on not only how much water we use, but also the longterm impacts of where we use it.

We are committed to water stewardship and have targets, initiatives and goals across our operations to reduce our impacts and be a positive actor in the river basins where we operate:

• At AstraZeneca sites: Decoupling water demand from business growth with our 2015-2025 global water efficiency goal key performance indicators; aspiring to develop context-based science-based water targets.

• In drug development: Adopting Resource Efficiency targets to reduce the water demand of the drugs we develop; conducting life Cycle Assessments to calculate the water footprint across the whole product life cycle including the raw materials used to make the drug substance.

• Maintaining water quality: Preventing pollution by applying safe discharge limits for active pharmaceutical ingredients produced or formulated our manufacturing operation.

• In our supply chain: Applying these safe discharge limits across our supply chain to prevent pollution from supplying that manufacture active pharmaceutical ingredients for us; Implementing a Supplier Sustainability Framework.

• In the communities where we operate: Supporting basin-level collective action; leading the development of science-based water targets. Starting in 2024, we will invest $5 million per year to fund nature restoration and water stewardship projects in the communities where we operate.