The recent unprecedented Ebola Virus Disease (EVD) epidemic in West Africa highlighted the need for the establishment of a public health institute in Liberia, which supports national health delivery services. With the plan to revitalize health services in the country, it was essential for the Government of Liberia to establish a National Public Health Institute of Liberia (NPHIL). In collaboration with the Ministry of Health, NPHIL strengthens existing infection prevention and control efforts, laboratories, surveillance, infectious disease control, public health capacity building, response to outbreaks, and monitoring of diseases with epidemic potential.